The NFL season may only be entering Week 3, but the drama is already hitting high gear as injuries, early-season struggles, and unexpected challenges dominate the headlines. From Joe Burrow’s latest setback to Patrick Mahomes’ rare rough patch, and a group of teams desperately trying to avoid an 0-3 start, here are five key storylines you need to know going into the weekend.

Cincinnati Bengals quarterback Joe Burrow has been sidelined once again, this time with a turf toe injury that requires surgery. Placed on injured reserve Tuesday, Burrow is expected to miss at least three months, according to reports, derailing yet another season before it has truly gained momentum. For the Bengals, it’s a familiar and frustrating cycle of injuries that has repeatedly hampered their playoff ambitions.

Still, Cincinnati does have some reason for optimism, opening the season 2-0 for the first time since 2018, giving the team breathing room as they adjust. Backup Jake Browning will now take over under center as the Bengals travel to face the Minnesota Vikings, who sit at 1-1 and are dealing with quarterback problems of their own.

Minnesota’s rookie quarterback J.J. McCarthy has been ruled out for two to four weeks with an ankle injury, forcing veteran Carson Wentz into the spotlight. Wentz, once a franchise quarterback turned journeyman, now has another chance to prove he can still lead an NFL offense in meaningful games.

Meanwhile, Patrick Mahomes and the Kansas City Chiefs are navigating uncharted waters. The superstar quarterback, usually known for his dominance, is facing increased scrutiny after an uncharacteristically shaky start to the season. While Kansas City’s record is still solid, Mahomes’ struggles have raised questions about whether the reigning champions can stay on top amid stronger competition and lingering offensive issues.

Beyond the marquee names, several teams are already in danger of slipping into an 0-3 hole—a start that historically makes it almost impossible to reach the playoffs. With desperation setting in early, fans can expect intensity to ramp up across the league in Week 3 matchups.

As the season unfolds, Week 3 promises a mix of high-stakes drama, redemption opportunities, and the kind of unpredictability that keeps the NFL must-watch entertainment every weekend.